NCII: About NCII

10 Years of NCII - A Decade of Innovation and Exchange

Starting in 2015 as an unknown gathering, NCII has developed over the past 10 years into an important conference in the field of innate immunity.
Surrounded by the beautiful medieval city of Tübingen, over 200 participants per year have been welcomed, including international experts, pioneers and innovators.

Over the past few years, it has been a great honour for us to host renowned speakers such as Christiane Nüsslein-Volhard (Nobel Prize in Physiology or Medicine in 1995), Louis Staudt (Director of the Center for Cancer Genomics at the NIH National Cancer Institute), Bruce Beutler (Nobel Prize in Physiology or Medicine in 2011), Richard A. Flavell (Sterling Professor of Immunobiology at Yale School of Medicine) and Yasmine Belkaid (President of the Institut Pasteur) who have significantly expanded our understanding of immunity with their contributions.
For a decade, the NCII has provided an important platform for the exchange of new research in the field of innate immunity, and we are looking forward to celebrating this special anniversary with you from June 10 to 13 at the Eberhard-Karls-University Tübingen.

Here you can find a short review of our previous conferences:

Date	31 May - 02 June 2023
Location	Hörsaalzentrum Morgenstelle
Participants	182
Invited talks/speakers	How cells defend their cytosol against invasive bacteria (Felix Randow) Activation of antitumor immunity by bacteria-derived signals - pyroptosis and beyond (Feng Shao) Inflammasomes at the crossroads of basic science and therapeutic intervention (Hao Wu) A transient and spatially-restricted subset of resident Kupffer Cells induced by lipid uptake (Charlotte Scott) Arginine methylation promotes monocyte extravasation driving chronic obstructive pulmonary disease (Ali Önder Yildirim) Fungal β-glucan and the regulation of innate immune responses (Jessica Quintin) Trained immunity in microglia identifies regulators of disease-associated activation states (Jonas Neher) IL-26 - a new player in skin inflammation and disease (Michel Gilliet) Neutrophil extracellular traps promote S. aureus skin colonization by induction of oxidative stress in the skin and downregulation of epidermal barrier genes (Jule Focken) Expansion microscopy of neutrophil nuclear structure and extracellular traps (Jason Holsapple) Mast cell secretory granules serve as endogenous C-type lectin receptor ligands skewing dendritic cell function towards type II immunity (Johanna Kotrba) Fumarate hydratase controls macrophage cytokine production (Luke O'Neill) Identification of an endogenous lipid driving metaflammation (Eicke Latz) Intestinal barrier cell remodelling in IBD (Alison Simmons) The central role of RNase T2 in RNA recognition in the endolysosome (Veit Hornung) Innate immune detection of nuclear DNA damage and replication stress (Leonie Unterholzner) NK cell clonality and inflammatory memory (Chiara Romagnani) Attenuated Salmonella blocks cancer metastasis by activating NK cells in an IFN-γ-dependent manner (Jian-Dong Huang) Reprogramming of NK cells by disseminated tumor cells as a barrier to anti-metastatic immunity (Jan Böttcher) APC-like activity of tumor-draining lymph node neutrophils in cancer (Jadwiga Jablonska) Metabolic control in the liver by innate immunity (Matthias Heikenwälder)

Date	26 - 28 May 2021
Location	digital
Participants	202
Invited talks/speakers	Trained immunity – a memory for innate host defense (Mihai G. Netea) Adventures in Inflammation Research (Luke O'Neill) Tumor-induced reshuffling of lipid composition on ER membrane sustains macrophage survival and pro-tumorigenic activity (Ping-Chih Ho) Why so many ways to die? (Vishva Dixit) T-bet controls lymph node formation by regulating embryonic innate lymphoid cell differentiation (Chiara Romagnani) Harnessing Innate Lymphoid Cells against solid cancer (Adelheid Cerwenka) NLRP3 activation mechanisms (Eicke Latz) Exploring skin cell heterogeneity (Fiona M. Watt) Speck-tacular inflammasomes (Hao Wu) How cells ubiquitylate cytosol-invading bacteria (Felix Randow) A choreographed innate immune response to repair (Paul Kubes) Necroptosis-driven inflammation (Veit Hornung) The dark side of PD-1 – mechanisms of T cell lymphoma (Jürgen Ruland) The cGAS-STING pathway and immunopathology (Andrea Ablasser) Microbiota-centered Interventions for immuno-oncology 2.0 (Laurence Zitvogel)

Date	12 - 14 June 2019
Location	Hörsaalzentrum Morgenstelle
Participants	200
Invited talks/speakers	New ways to die – caspases, kinases and everything in-between (Vishva Dixit) GBPs and caspase-4 assemble the non-canonical inflammasome at the outer membrane of cytosolic bacteria (Petr Broz) Heterogeneity of neutrophils (Andres Hidalgo Alonso) Innate immune cell dynamics in the tissue interstitium (Tim Lämmermann) Creating immune phenotypes with random germline mutagenesis and solving them in real time (Bruce Beutler) T cell-centric view of innate lymphoid cell differentiation (James di Santo) Transcriptional delineation of human ILCs at the single-cell level (Jenny Mjosberg) Trained immunity – a memory for innate host defense (Mihai G. Netea) Metabolic reprogramming regulates macrophage transcription (Eicke Latz) Skin antifungal immunity at the interface between homeostasis and disease (Salomé Leibundgut-Landmann) C-type lectins and the control of adaptive anti-fungal immunity (Gordon D. Brown) Host micro biome interactions in health and diesease (Eran Elinav) Genetic dissection of TLR4 signaling in human myeloid cells (Veit Hornung) Using the immune system’s trojan horse for vaccination (Jan Rehwinkel) Orchestration of novel human T cell properties by the inflammasome (Christina Zielinski) RIP kinase signalling in cell death and inflammation (Manolis Pasparakis) Microbiome in immunooncology (Laurence Zitvogel) Targeting STING in senescence with small-molecule antagonists (Andrea Ablasser) On the role of platelets and Kupffer cells in NASH and liver cancer formation (Mathias Heikenwälder)

Date	27 - 29 March 2017
Location	Tübingen
Participants	200
Invited talks/speakers	PRRs and the control of cytotoxic responses (Greta Guarda) The function of RIG-I’s ATPase in distinguishing self and non-self (Karl-Peter Hopfner) Cell-autonomous and bystander cell responses to inflammasome activation (Eicke Latz) The NLRP3 inflammasome in human sepsis (Pablo Pelegrín) Cancer as a disease of the symbiont/metaorganism (Giorgio Trinchieri) Antigen specificity of adaptive NK cells (Chiara Romagnani) Tissue residency of innate lymphoid cells? (Georg Gasteiger) NETosis in the oral cavity – A model of neutrophil fate at mucosal surfaces? (Ole Sørensen) Innate immune cell swarming at sites of inflammation and infection (Tim Lämmermann) Immunity and the microbiota at the host/fungi interface (Luigina Romani) C-type lectins in immunity – new insights (Gordon Brown) Spingolipids in host-bacterial interactions (Ruth Ley) The inner mucus layer and sentinel goblet cell make up the first and second line of colon defense (Gunnar C. Hansson) Remote control of antitumoral immunity by the gut microbiota (Mathias Chamaillard) Sensing and responding to viruses (Caetano Reis e Sousa) Intracellular innate immune sensing of HIV (Nicolas Manel) Antimicrobial – peptides in innate immunity of the skin (Michel Gilliet) The functional YIN and YANG of cutaneous TLR2 sensing (Tilo Biedermann) Therapy of lymphoma inspired by functional and structural genomics (Louis Staudt) ITAM Receptor Signals in Inflammation and Oncogenesis (Jürgen Ruland)

Date	23 - 25 September 2015
Location	Tübingen
Participants	200
Invited talks/speakers	The Drosophila antimicrobial response – a paradigm for innate immunity (Jules Hoffmann) How the discovery of Toll-like receptors changed Immunology (Luke O’Neill) Remote control of intestinal tumorigenesis by the gut microbiota (Matthias Chamaillard) Posttranslational regulation of the NLRP3 inflammasome (Eicke Latz) Anti Inflammatory Properties of the Interleukin-1 Homologue IL-37 (Philip Bufler) The discovery of the Toll Gene in Drosophila pattern formation (Christiane Nüsslein-Volhard) Innate lymphoid cells – how tissue-resident immune cells adapt organ function (Andreas Diefenbach) Crosstalk of innate lymphoid cells with the adaptive immune system (Daniela Finke) Activation and differentiation of group 3 innate lymphoid cells (Chiara Romagnani) Innate lymphocytes-regulation by C-type lectin-like receptors (Alexander Steinle) Basophil-mediated protective immunity and allergic inflamemation (David Voehringer) Origin of and signals directing monocytic MDSC generation (Manfred Lutz) Implications of the microbiota in respiratory disease (Eva Gollwitzer) Ontogeny of the mucosal host-microbe interaction in the intestine (Matthias Hornef) Antifungal defense at mucosal barriers (Salome Leibundgut-Landmann) Novel insights in antifungal host-defense (Frank van de Veerdonk) Card 9 dependent signals in inflammation (Jürgen Ruland) The Proteome under viral attack (Andreas Pichlmair) Intracellular nucleic acid sensing by the innate immune system (Veit Hornung) Antimicrobial peptide in nucleic acid-driven innate immunity (Michel Gilliet) Origin and functional commitment of dermal macrophages (Philipp Henneke)